Association between a serotonin transporter promoter polymorphism (5HTTLPR) and personality disorder traits in a community sample
نویسندگان
چکیده
منابع مشابه
Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample.
The serotonin transporter (5-HTT) regulates serotonergic neurotransmission and is thought to influence emotion. A 5-HTT-linked polymorphic region (5-HTTLPR) has two common variants, short (s) and long (l). We previously found population and within-family associations between the lower-expressing s allele and neuroticism, a trait related to anxiety, hostility, and depression, on a standard measu...
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Anxiety-related personality traits, such as NEO neuroticism and TCI/TPQ harm avoidance, have been shown to have significant genetic components. To date, however, no specific genetic variants that contribute to these traits have been conclusively identified. At least 26 studies have investigated a putative association between a functional serotonin transporter promoter polymorphism (5-HTTLPR) an...
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Borderline personality disorder (BPD) is characterized by a pervasive pattern of instability in regulation of emotion, interpersonal relationships, self-image, and impulse control beginning in early adulthood. BPD affects about 1-2% of the general population and has a high mortality rate as a result of suicide and impulsive behaviour. The serotonin transporter gene (5-HTT) is considered as a ca...
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Background: An epidemiological study in the USA recently reported that variations in the serotonin transporter gene-linked polymorphic region (5HTTLPR) can influence subjective well-being or happiness; specifically, individuals with long polymorphisms (L-allele carriers), associated with increased serotonin reuptake activity, reported significantly higher levels of life satisfaction compared to...
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Association between common intelligence quotient (IQ) and S and L alleles of functional 5HTTLPR polymorphism causing respectively low and high expression of human serotonin transporter coding gene was studied in young (19-35 years, 50 men and 76 women) and older (>55 years, 39 men and 43 women) Caucasian subjects. They were students, scientists, technicians and administrative staff of Novosibir...
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ژورنال
عنوان ژورنال: Journal of Psychiatric Research
سال: 2011
ISSN: 0022-3956
DOI: 10.1016/j.jpsychires.2011.03.003